Polymers and Plastics

Applications of Polyme...

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{"id":11242240964,"title":"Applications of Polymers in Drug Delivery","handle":"9781847358516","description":"\u003ch5\u003eDescription\u003c\/h5\u003e\nAuthor: Edited by Ambikanandan Misra and Aliasgar Shahiwala \u003cbr\u003eISBN 9781847358516 \u003cbr\u003e\u003cbr\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cspan\u003ePublished: 2014\u003cbr\u003e\u003c\/span\u003epage 546\n\u003ch5\u003eSummary\u003c\/h5\u003e\nUse of polymers has become indispensable in the field of drug delivery. Polymers play a crucial role in modulating drug delivery to exploit maximum therapeutic benefits and have been fundamental in the successful development of several novel drug delivery systems that are now available. \u003cbr\u003e\u003cbr\u003eThis book provides details of the applications of polymeric drug delivery systems that will be of interest to researchers in industries and academia. It describes the development of polymeric systems ranging from the conventional dosage forms up to the most recent smart systems. The regulatory and intellectual property aspects, as well as the clinical applicability of polymeric drug delivery systems, are also discussed.\u003cbr\u003e\u003cbr\u003eEach different drug delivery route is discussed in a separate chapter of the book. All major routes of drug delivery have been covered to provide the reader with a panoramic as well as an in-depth view of the developments in polymer-based drug delivery systems. Appendices are included which incorporate useful pharmaceutical properties of the polymers and important polymeric applications for various drug delivery routes.\n\u003ch5\u003eTable of Contents\u003c\/h5\u003e\n1 Polymers in Drug Delivery Systems \u003cbr\u003e1.1 Introduction \u003cbr\u003e1.2 Fundamentals of a Polymeric Drug Delivery System \u003cbr\u003e1.2.1 Factors That Affect Drug Release from Polymers \u003cbr\u003e1.2.2 Mechanism of Controlled Release \u003cbr\u003e1.2.2.1 Temporal Controlled Systems \u003cbr\u003e1.2.2.1.1 Delayed Dissolution \u003cbr\u003e1.2.2.1.2 Diffusion Controlled \u003cbr\u003e1.2.2.1.2.1 Release from Monolithic\/Matrix Systems \u003cbr\u003e1.2.2.1.2.2 Reservoir Type Systems \u003cbr\u003e1.2.2.1.3 Osmotic\/Solvent Controlled Systems \u003cbr\u003e1.2.2.1.4 Swelling Controlled \u003cbr\u003e1.2.2.1.5 Environmental\/Stimuli Responsive Systems \u003cbr\u003e1.2.2.1.5.1 Thermo-responsive Polymers \u003cbr\u003e1.2.2.1.5.2 pH-Responsive Polymers \u003cbr\u003e1.2.2.1.5.3 Dual Stimuli-Responsive Polymers \u003cbr\u003e1.2.2.2 Distribution Controlled Systems \u003cbr\u003e1.2.2.3 Biodegradable\/Degradation and Erosion Controlled Systems \u003cbr\u003e1.3 Polymer Delivery Systems \u003cbr\u003e1.3.1 Oral Drug Delivery System \u003cbr\u003e1.3.1.1 Gastro Retentive Drug Delivery System \u003cbr\u003e1.3.1.1.1 Floating System \u003cbr\u003e1.3.1.1.2 Hydrodynamically Balanced Systems \u003cbr\u003e1.3.1.1.3 Bio\/Mucoadhesive Systems \u003cbr\u003e1.3.1.1.4 Hydration-mediated Adhesion \u003cbr\u003e1.3.1.1.5 Swelling Systems \u003cbr\u003e1.3.1.2 Colon Specific Drug Delivery System \u003cbr\u003e1.3.1.2.1 pH Sensitive Systems \u003cbr\u003e1.3.1.2.1.1 Coating with pH Dependent Polymers\u003cbr\u003e1.3.1.2.1.2 Coating with pH Independent Biodegradable Polymers \u003cbr\u003e1.3.1.2.2 Time Controlled\/Dependent System \u003cbr\u003e1.3.1.2.3 Pressure Controlled System\u003cbr\u003e1.3.1.2.4 Osmotically Controlled System \u003cbr\u003e1.3.1.2.5 Pulsatile Drug Delivery System \u003cbr\u003e1.3.1.3 Ion-exchange Based Drug Delivery System \u003cbr\u003e1.3.2 Transdermal Drug Delivery System \u003cbr\u003e1.3.2.1 Classification of Transdermal Drug Delivery \u003cbr\u003e1.3.2.1.1 Reservoir Systems \u003cbr\u003e1.3.2.1.2 Drug-in-adhesive Systems \u003cbr\u003e1.3.2.1.3 Matrix-dispersion Systems \u003cbr\u003e1.3.2.1.4 Micro-reservoir Systems \u003cbr\u003e1.3.2.2 Polymers for Transdermal Drug Delivery System \u003cbr\u003e1.3.2.2.1 Natural Polymers \u003cbr\u003e1.3.2.2.2 Synthetic Polymers \u003cbr\u003e1.3.2.2.2.1 Pressure Sensitive Adhesives \u003cbr\u003e1.3.2.2.2.2 Backing Membrane \u003cbr\u003e1.3.2.2.2.3 Release Liner \u003cbr\u003e1.3.3 Mucoadhesive Drug Delivery System \u003cbr\u003e1.3.3.1 Hydrophilic Polymers \u003cbr\u003e1.3.3.2 Hydrogels \u003cbr\u003e1.3.3.3 Thiolated Polymers \u003cbr\u003e1.3.3.4 Lectin-based Polymers \u003cbr\u003e1.3.4 Ocular Drug Delivery System \u003cbr\u003e1.3.4.1 Polymers used in Conventional Ocular Delivery \u003cbr\u003e1.3.4.1.1 Liquid Dosage Forms \u003cbr\u003e1.3.4.1.2 Semi-solid Dosage Forms \u003cbr\u003e1.3.4.2 Polymers used in Ophthalmic Inserts\/Films \u003cbr\u003e1.3.5 Implant and Parenteral Drug Delivery System\u003cbr\u003e1.3.5.1 Surgical Implants \u003cbr\u003e1.3.5.2 Microspheres\u003cbr\u003e1.3.5.2.1 Bioadhesive Microspheres \u003cbr\u003e1.3.5.2.2 Floating Microspheres \u003cbr\u003e1.3.5.2.3 Polymeric Microspheres \u003cbr\u003e1.3.5.2.3.1 Biodegradable Polymeric Microspheres \u003cbr\u003e1.3.5.2.3.2 Synthetic Polymeric Microspheres\u003cbr\u003e1.3.5.3 Injectable In Situ Gel \u003cbr\u003e1.3.5.3.1 Thermoplastic Paste \u003cbr\u003e1.3.5.3.2 In Situ Crosslinking System \u003cbr\u003e1.3.5.3.3 In Situ Polymer Precipitation\u003cbr\u003e1.3.5.3.4 Thermally-induced Gelling \u003cbr\u003e1.4 Recent Advancements in Polymer Architecture and Drug Delivery\u003cbr\u003e1.4.1 Block Copolymers \u003cbr\u003e1.4.2 Polymersomes\u003cbr\u003e1.4.3 Hyperbranched Polymers \u003cbr\u003e1.4.4 Graft Polymers \u003cbr\u003e1.4.5 Star Polymers \u003cbr\u003e1.4.6 Dendrimers \u003cbr\u003e1.5 Recent Patent Trends in Polymeric Drug Delivery\u003cbr\u003e1.6 Future Developments \u003cbr\u003e\u003cbr\u003e2 Applications of Polymers in Buccal Drug Delivery \u003cbr\u003e2.1 Introduction \u003cbr\u003e2.1.1 Advantages of Buccal Drug Delivery \u003cbr\u003e2.1.2 Disadvantages of Buccal Drug Delivery \u003cbr\u003e2.2 Factors Affecting Bioadhesion in the Oral Cavity \u003cbr\u003e2.2.1 Functional Groups2\u003cbr\u003e2.2.2 Molecular Weight \u003cbr\u003e2.2.3 Flexibility \u003cbr\u003e2.2.4 Crosslinking Density \u003cbr\u003e2.2.5 Charge\u003cbr\u003e2.2.6 Concentration \u003cbr\u003e2.2.7 Hydration (Swelling) \u003cbr\u003e2.2.8 Environmental Factors\u003cbr\u003e2.3 Buccal Polymeric Dosage Forms \u003cbr\u003e2.3.1 Semi-solids \u003cbr\u003e2.3.2 Solids\u003cbr\u003e2.3.2.1 Powder Dosage Forms\u003cbr\u003e2.3.2.2 Tablets \u003cbr\u003e2.3.2.3 Polymeric Films and Patches \u003cbr\u003e2.4 Novel Carriers \u003cbr\u003e2.5 Conclusions \u003cbr\u003e\u003cbr\u003e3 Applications of Polymers in Gastric Drug Delivery \u003cbr\u003e3.1 Introduction \u003cbr\u003e3.2 Need for Gastric Retention \u003cbr\u003e3.3 Benefits and Pitfalls\u003cbr\u003e3.4 Gastrointestinal Tract \u003cbr\u003e3.4.1 Anatomy of the Gastrointestinal Tract \u003cbr\u003e3.4.1.1 Mucus Layer\u003cbr\u003e3.4.2 Basic Gastrointestinal Tract Physiology \u003cbr\u003e3.5 Factors Affecting Gastric Retention \u003cbr\u003e3.6 Polymers in Gastro Retentive Drug Delivery Systems \u003cbr\u003e3.6.1 Cellulosic Hydrocolloids\u003cbr\u003e3.6.2 Carbomers or Carbopol® \u003cbr\u003e3.6.3 Xanthan Gum\u003cbr\u003e3.6.4 Guar Gum \u003cbr\u003e3.6.5 Chitosan\u003cbr\u003e3.6.6 Eudragit® Polymers\u003cbr\u003e3.6.7 Alginate Polymers \u003cbr\u003e3.6.8 Lectin-based Polymers\u003cbr\u003e3.6.9 Thiolated Polymers \u003cbr\u003e3.6.10 Miscellaneous Polymers\u003cbr\u003e3.7 Evaluation of Gastro Retentive Drug Delivery Systems \u003cbr\u003e3.7.1 In Vitro Evaluation\u003cbr\u003e3.7.1.1 Floating Systems\u003cbr\u003e3.7.1.2 Swelling Systems \u003cbr\u003e3.7.2 In Vitro Release \u003cbr\u003e3.7.3 In Vivo Evaluation \u003cbr\u003e3.8 Application of Polymers in Gastric Delivery Systems \u003cbr\u003e3.8.1 Floating Drug Delivery System\u003cbr\u003e3.8.1.1 Effervescent Floating Dosage Forms \u003cbr\u003e3.8.1.2 Non-effervescent Floating Dosage Forms \u003cbr\u003e3.8.2 Bioadhesive Drug Delivery System \u003cbr\u003e3.8.3 Swelling and Expanding Delivery System \u003cbr\u003e3.8.4 Combinational\/Amalgamative Delivery System\u003cbr\u003e3.8.4.1 Bioadhesive and Floating Approach\u003cbr\u003e3.8.4.2 Swellable and Floating Approach\u003cbr\u003e3.8.4.3 Bioadhesion and Swelling Approach \u003cbr\u003e3.8.4.4 Bioadhesion and High-density Approach\u003cbr\u003e3.8.5 Microparticulate Delivery System\u003cbr\u003e3.8.5.1 Microballoons\/Hollow Microspheres\u003cbr\u003e3.8.5.2 Alginate Beads\u003cbr\u003e3.8.5.3 Floating Granules \u003cbr\u003e3.8.5.4 Super Porous Hydrogel Systems \u003cbr\u003e3.8.5.5 Raft Forming Systems \u003cbr\u003e3.9 Conclusion \u003cbr\u003e4 Applications of Polymers in Small Intestinal Drug Deliver\u003cbr\u003e4.1 Introduction \u003cbr\u003e4.1.1 Advantages of Polymer Coating \u003cbr\u003e4.1.2 Benefit from Polymer Coatings with Sustained Release \u003cbr\u003e4.2 Physiology of the Small Intestine\u003cbr\u003e4.2.1 Mucosa of Small Intestine\u003cbr\u003e4.2.2 Secretion into the Small Intestine\u003cbr\u003e4.2.2.1 Glands\u003cbr\u003e4.2.2.2 Pancreatic Secretion \u003cbr\u003e4.2.2.3 Biliary Secretions\u003cbr\u003e4.2.2.4 Digestion of the Food Nutrients \u003cbr\u003e4.2.3 pH of the Small Intestine\u003cbr\u003e4.2.4 Gastrointestinal Motility \u003cbr\u003e4.2.5 Transit of the Dosage Form through the Small Intestine \u003cbr\u003e4.2.6 Drug Absorption through Small Intestine \u003cbr\u003e4.2.7 Peyer’s Patch \u003cbr\u003e4.3 Scope of Small Intestinal Drug Delivery \u003cbr\u003e4.4 Polymers used in Small Intestinal Drug Delivery\u003cbr\u003e4.4.1 Natural Polymers \u003cbr\u003e4.4.1.1 Chitosan \u003cbr\u003e4.4.1.2 Shellac\u003cbr\u003e4.4.1.3 Sodium Alginate \u003cbr\u003e4.4.2 Synthetic Polymers \u003cbr\u003e4.4.2.1 Polyacrylic acid Derivatives (Carbomer) \u003cbr\u003e4.4.2.2 Cellulose Derivatives \u003cbr\u003e4.4.2.2.1 Cellulose Acetate Phthalate \u003cbr\u003e4.4.2.2.2 Hydroxypropyl Methyl Cellulose Phthalate \u003cbr\u003e4.4.2.2.3 Polyvinyl Acetate Phthalate\u003cbr\u003e4.4.2.2.4 Hydroxypropyl Methyl Cellulose Acetate Succinate\u003cbr\u003e4.4.2.2.5 Cellulose Acetate Trimelliate\u003cbr\u003e4.4.2.3 Polymethacrylates \u003cbr\u003e4.4.2.3.1 Polymethacrylic Acid-co-ethyl Acrylate as Aqueous Dispersion. \u003cbr\u003e4.4.2.3.2 Polymethacrylic Acid-co-ethyl Acrylate as Powder\u003cbr\u003e4.4.2.3.3 Polyethyl Acrylate-co-methyl Methacrylate-co-trimethylammonioethyl Methacrylate Chloride\u003cbr\u003e4.4.2.3.4 Polymethacrylic Acid-co-methyl Methacrylate\u003cbr\u003e4.4.2.3.5 Polymethacrylic Acid-co-methylmethacrylate \u003cbr\u003e4.4.2.3.5.1 Methacrylic Acid - Methyl Methacrylate Copolymer (1:2)\u003cbr\u003e4.4.2.3.5.2 Polymethacrylic Acid-co-methyl Methacrylate (1:2) \u003cbr\u003e4.5 Benefits of Polymers in Small Intestinal Drug Delivery \u003cbr\u003e4.5.1 Hydroxypropyl Methyl Cellulose Phthalate\u003cbr\u003e4.5.2 Hydroxypropyl Methyl Cellulose Acetate Succinate. \u003cbr\u003e4.5.3 Hydroxypropyl Methyl Cellulose Acetate Maleate. \u003cbr\u003e4.5.4 Methacrylic Acid Polymers and Copolymers \u003cbr\u003e4.5.5 Chitosan \u003cbr\u003e4.5.6 Chitosan and Methacrylic Acid Polymer and Copolymers\u003cbr\u003e4.5.7 Sodium Alginate \u003cbr\u003e4.5.8 Thiolated Tamarind Seed Polysaccharide\u003cbr\u003e4.6 Conclusion \u003cbr\u003e\u003cbr\u003e5 Application of Polymers in Transdermal Drug Delivery\u003cbr\u003e5.1 Introduction \u003cbr\u003e5.2 Advantages of Drug Delivery via the Transdermal Route \u003cbr\u003e5.3 Mechanism of Drug Absorption in Transdermal Drug Delivery \u003cbr\u003eSystems\u003cbr\u003e5.4 Factors Affecting Transdermal Permeation\u003cbr\u003e5.4.1 Physicochemical Properties of Penetrant Molecules \u003cbr\u003e5.4.2 Physicochemical Properties of the Drug Delivery \u003cbr\u003eSystem\u003cbr\u003e5.4.2.1 Release Characteristics\u003cbr\u003e5.4.2.2 Composition of the Drug Delivery Systems\u003cbr\u003e5.4.2.3 Drug Permeation Enhancer \u003cbr\u003e5.4.3 Physiological and Pathological Conditions of the Skin\u003cbr\u003e5.5 Types of Transdermal Drug Delivery Systems\u003cbr\u003e5.5.1 Formulation Aspects\u003cbr\u003e5.5.1.1 Matrix Systems \u003cbr\u003e5.5.1.2 Reservoir Systems \u003cbr\u003e5.5.1.3 Micro-reservoir Systems\u003cbr\u003e5.5.2 Based on Release Mechanism\u003cbr\u003e5.5.2.1 Passive Transdermal Drug Delivery Systems. \u003cbr\u003e5.5.2.2 Active Transdermal Drug Delivery Systems \u003cbr\u003e5.6 Role of Polymers in Transdermal Drug Delivery Systems \u003cbr\u003e5.6.1 Matrix Formers\u003cbr\u003e5.6.1.1 Crosslinked Polyethylene Glycol \u003cbr\u003e5.6.1.2 Acrylic-acid Matrices\u003cbr\u003e5.6.1.3 Ethyl Cellulose and Polyvinyl Pyrrolidone \u003cbr\u003e5.6.1.4 Hydroxypropyl Methylcellulose \u003cbr\u003e5.6.1.5 Chitosan \u003cbr\u003e5.6.1.6 Ethyl Vinyl Acetate Copolymer \u003cbr\u003e5.6.1.7 Gum Copal\u003cbr\u003e5.6.1.8 Damar Batu \u003cbr\u003e5.6.1.9 Organogels \u003cbr\u003e5.6.2 Rate-controlling Membrane\u003cbr\u003e5.6.2.1 Ethylene Vinyl Acetate Copolymer \u003cbr\u003e5.6.2.2 Polyethylene \u003cbr\u003e5.6.2.3 Polyurethane\u003cbr\u003e5.6.2.4 Crosslinked Sodium Alginate\u003cbr\u003e5.6.2.5 Copolymer of 2-Hydroxy-3- Phenoxypropylacrylate, 4-Hydroxybutyl Acrylate and Sec-Butyl Tiglate\u003cbr\u003e5.6.2.6 Polysulfone, Polyvinylidene Fluoride (Hydrophilic Membrane)\u003cbr\u003e5.6.2.7 Polytetrafluoroethylene (Hydrophobic Membrane) \u003cbr\u003e5.6.2.8 Crosslinked Polyvinyl Alcohol \u003cbr\u003e5.6.2.9 Cellulose Acetate \u003cbr\u003e5.6.2.10 Eudragit® \u003cbr\u003e5.6.2.11 Chitosan \u003cbr\u003e5.6.3 Pressure Sensitive Adhesives \u003cbr\u003e5.6.3.1 Polyisobutylenes \u003cbr\u003e5.6.3.2 Silicones\u003cbr\u003e5.6.3.3 Acrylics \u003cbr\u003e5.6.3.4 Hot-melt Pressure Sensitive Adhesives \u003cbr\u003e5.6.3.5 Hydrogel Pressure Sensitive Adhesives\u003cbr\u003e5.6.3.6 Hydrophilic Pressure Sensitive Adhesives \u003cbr\u003e5.6.3.7 Polyurethanes \u003cbr\u003e5.6.4 Backing Layer\/Membranes\u003cbr\u003e5.6.5 Release Liner \u003cbr\u003e5.6.6 Polymers to Enhance Skin Permeation\u003cbr\u003e5.6.6.1 Penetration Enhancers\u003cbr\u003e5.6.6.2 Pulsed Delivery \u003cbr\u003e5.7 Future Perspectives\u003cbr\u003e5.8 Conclusion \u003cbr\u003e\u003cbr\u003e6 Application of Polymers in Peyer’s Patch Targeting \u003cbr\u003e6.1 Introduction \u003cbr\u003e6.2 Peyer’s Patch Physiology, Structure, and Function \u003cbr\u003e6.2.1 General Properties and Peyer’s Patch Distribution in Different Species \u003cbr\u003e6.2.2 M Cell Structure and Function\u003cbr\u003e6.3 Strategies for Achieving Effective Delivery to the Peyer’s Patch \u003cbr\u003e6.3.1 General Principles of Peyer’s Patch Delivery\u003cbr\u003e6.3.2 Effect of Particle Size on Peyer’s Patch \u003cbr\u003e6.4 Peyer’s Patch Drug Delivery using Polymeric Carriers\u003cbr\u003e6.4.1 Polylactide-co-glycolic Acid \u003cbr\u003e6.4.2 Polylactic Acid \u003cbr\u003e6.4.3 Poly-D,L-lactide-co-glycolide \u003cbr\u003e6.4.4 Polystyrene \u003cbr\u003e6.4.5 Chitosan \u003cbr\u003e6.4.6 Other Polymer Carrier\u003cbr\u003e6.5 Uptake of Particles by Peyer’s Patches\u003cbr\u003e6.6 Targets for Peyer’s Patch Delivery \u003cbr\u003e6.6.1 Lectin-mediated Targeting \u003cbr\u003e6.6.2 Microbial Protein-mediated Targeting \u003cbr\u003e6.6.2.1 Yersinia \u003cbr\u003e6.6.2.2 Salmonella \u003cbr\u003e6.6.2.3 Cholera Toxin \u003cbr\u003e6.6.2.4 Virus Protein \u003cbr\u003e6.6.3 Vitamin B12 Mediated Targeting\u003cbr\u003e6.6.4 Non-Peptide Ligand Mediated Targeting \u003cbr\u003e6.6.5 Peptide Ligand Mediated Targeting \u003cbr\u003e6.6.6 Claudin-4 Mediated Targeting \u003cbr\u003e6.6.7 Monoclonal Antibody Mediated Targeting \u003cbr\u003e6.6.8 M Cell Homing Peptide Targeting \u003cbr\u003e6.6.9 Immunoglobulin A Conjugates Targeting\u003cbr\u003e6.7 Summary and Conclusions \u003cbr\u003e7 Applications of Polymers in Colon Drug Delivery \u003cbr\u003e7.1 Introduction \u003cbr\u003e7.2 Anatomy of the Colon \u003cbr\u003e7.3 Correlation between Physiological Factors and use of Polymers in Colon Drug Delivery Systems\u003cbr\u003e7.3.1 The pH of the Gastrointestinal Tract \u003cbr\u003e7.3.2 Gastrointestinal Transit Time \u003cbr\u003e7.3.3 Colonic Motility \u003cbr\u003e7.3.4 Colonic Microflora\u003cbr\u003e7.3.5 Colonic Absorption\u003cbr\u003e7.4 Advantages of Colon Drug Delivery Systems\u003cbr\u003e7.5 Disadvantages of Colon Drug Delivery Systems \u003cbr\u003e7.6 Polymers for Colon Drug Delivery Systems \u003cbr\u003e7.6.1 Pectin\u003cbr\u003e7.6.2 Guar Gum \u003cbr\u003e7.6.3 Chitosan \u003cbr\u003e7.6.4 Amylose \u003cbr\u003e7.6.5 Inulin \u003cbr\u003e7.6.6 Locust Bean Gum \u003cbr\u003e7.6.7 Chondroitin Sulfate \u003cbr\u003e7.6.8 Dextran \u003cbr\u003e7.6.9 Alginates \u003cbr\u003e7.6.10 Cyclodextrin \u003cbr\u003e7.6.11 Eudragit® \u003cbr\u003e7.6.12 Cellulose Ethers \u003cbr\u003e7.6.13 Ethyl Cellulose\u003cbr\u003e7.6.14 Polymers for Enteric Coating\u003cbr\u003e7.6.15 Polyvinyl Alcohol \u003cbr\u003e7.7 Application of Polymers in Colon Drug Delivery Systems\u003cbr\u003e7.7.1 System Dependent on pH \u003cbr\u003e7.7.2 System Dependent on Time\u003cbr\u003e7.7.2.1 Reservoir Systems with Rupturable Polymeric Coats \u003cbr\u003e7.7.2.2 Reservoir Systems with Erodible Polymeric Coats \u003cbr\u003e7.7.2.3 Reservoir Systems with Diffusive Polymeric Coats \u003cbr\u003e7.7.2.4 Capsular Systems with Release-controlling Polymeric Plugs \u003cbr\u003e7.7.2.5 Osmotic System \u003cbr\u003e7.7.3 Bacterially Triggered System \u003cbr\u003e7.7.3.1 Prodrug \u003cbr\u003e7.7.3.2 Polysaccharide-based Matrix, Reservoirs and Hydrogels\u003cbr\u003e7.7.4 Time- and pH-Dependent Systems \u003cbr\u003e7.7.5 Pressure Controlled Delivery Systems \u003cbr\u003e7.8 Conclusion\u003cbr\u003e\u003cbr\u003e8 Applications of Polymers in Parenteral Drug Delivery \u003cbr\u003e8.1 Introduction \u003cbr\u003e8.2 Parenteral Route for Drug Delivery\u003cbr\u003e8.2.1 Advantages of Parenteral Administration \u003cbr\u003e8.2.2 Disadvantages of Parenteral Administration\u003cbr\u003e8.3 In Vivo Distribution of Polymer \u003cbr\u003e8.4 Biodegradation\u003cbr\u003e8.4.1 Erosion \u003cbr\u003e8.4.2 Degradation Processes\u003cbr\u003e8.4.2.1 Chemical and Enzymic Oxidation \u003cbr\u003e8.4.2.2 Chemical and Enzymic Hydrolysis \u003cbr\u003e8.5 Polymers for Parenteral Delivery \u003cbr\u003e8.5.1 Non-degradable Polymers\u003cbr\u003e8.5.2 Biodegradable Polymers \u003cbr\u003e8.5.2.1 Synthetic Polymers \u003cbr\u003e8.5.2.1.1 Polyesters \u003cbr\u003e8.5.2.1.2 Polylactones \u003cbr\u003e8.5.2.1.3 Polyamino acids \u003cbr\u003e8.5.2.1.4 Polyphosphazenes \u003cbr\u003e8.5.2.1.5 Polyorthoesters \u003cbr\u003e8.5.2.1.6 Polyanhydrides \u003cbr\u003e8.5.2.2 Natural Polymers \u003cbr\u003e8.5.2.2.1 Collagen \u003cbr\u003e8.5.2.2.2 Gelatin \u003cbr\u003e8.5.2.2.3 Albumin \u003cbr\u003e8.5.2.2.4 Polysaccharides \u003cbr\u003e8.6 Polymeric Drug Delivery Carriers\u003cbr\u003e8.6.1 Polymeric Implants \u003cbr\u003e8.6.2 Microparticles \u003cbr\u003e8.6.3 Nanoparticles \u003cbr\u003e8.6.4 Polymeric Micelles \u003cbr\u003e8.6.5 Hydrogels \u003cbr\u003e8.6.6 Polymer-drug Conjugates \u003cbr\u003e8.7 Factors Influencing Polymeric Parenteral Delivery\u003cbr\u003e8.7.1 Particle Size \u003cbr\u003e8.7.2 Drug Loading \u003cbr\u003e8.7.3 Porosity \u003cbr\u003e8.7.4 Molecular Weight of the Polymer \u003cbr\u003e8.7.5 Crystallinity\u003cbr\u003e8.7.6 Hydrophobicity\u003cbr\u003e8.7.7 Drug-polymer Interactions \u003cbr\u003e8.7.8 Surface Properties: Charge and Modifications \u003cbr\u003e8.8 Summary \u003cbr\u003e\u003cbr\u003e9 Applications of Polymers in Rectal Drug Delivery\u003cbr\u003e9.1 Introduction \u003cbr\u003e9.2 Rectal Drug Delivery\u003cbr\u003e9.2.1 Anatomy and Physiology of the Rectum \u003cbr\u003e9.2.2 Absorption through the Rectum\u003cbr\u003e9.2.2.1 Mechanism of Absorption\u003cbr\u003e9.2.2.2 Factors Affecting Absorption\u003cbr\u003e9.3 Polymers used in Rectal Dosage Forms\u003cbr\u003e9.3.1 Solutions \u003cbr\u003e9.3.2 Semi-solids\/Hydrogels \u003cbr\u003e9.3.3 Suppositories \u003cbr\u003e9.3.4 In Situ Gels \u003cbr\u003e9.4 Conclusion \u003cbr\u003e\u003cbr\u003e10 Applications of Polymers in Vaginal Drug Delivery \u003cbr\u003e10.1 Anatomy and Physiology of the Vagina \u003cbr\u003e10.1.1 Vaginal pH \u003cbr\u003e10.1.2 Vaginal Microflora \u003cbr\u003e10.1.3 Cyclic Changes \u003cbr\u003e10.1.4 Vaginal Blood Supply\u003cbr\u003e10.2 The Vagina as a Site for Drug Delivery \u003cbr\u003e10.3 Vaginal Dosage Forms \u003cbr\u003e10.4 Polymers for Vaginal Drug Delivery \u003cbr\u003e10.4.1 Polyacrylates \u003cbr\u003e10.4.2 Chitosan \u003cbr\u003e10.4.3 Cellulose Derivatives \u003cbr\u003e10.4.4 Hyaluronic Acid Derivatives \u003cbr\u003e10.4.5 Carrageenan \u003cbr\u003e10.4.6 Polyethylene Glycols \u003cbr\u003e10.4.7 Gelatin \u003cbr\u003e10.4.8 Thiomers \u003cbr\u003e10.4.9 Poloxamers \u003cbr\u003e10.4.10 Pectin and Tragacanth \u003cbr\u003e10.4.11 Sodium Alginate \u003cbr\u003e10.4.12 Silicone Elastomers for Vaginal Rings \u003cbr\u003e10.4.13 Thermoplastic Polymers for Vaginal Rings \u003cbr\u003e10.4.14 Miscellaneous \u003cbr\u003e10.5 Toxicological Evaluation\u003cbr\u003e10.6 Conclusion \u003cbr\u003e\u003cbr\u003e11 Application of Polymers in Nasal Drug Delivery\u003cbr\u003e11.1 Introduction 379\u003cbr\u003e11.2 Nasal Anatomy and Physiology \u003cbr\u003e11.2.1 Nasal Vestibule \u003cbr\u003e11.2.2 Atrium \u003cbr\u003e11.2.3 Olfactory Region \u003cbr\u003e11.2.4 Respiratory Region \u003cbr\u003e11.2.5 Nasopharynx\u003cbr\u003e11.3 Biological Barriers in Nasal Absorption \u003cbr\u003e11.3.1 Mucus \u003cbr\u003e11.3.2 Nasal Mucociliary Clearance \u003cbr\u003e11.3.3 Enzymic Barrier\u003cbr\u003e11.3.4 P-Glycoprotein Efflux Transporters\u003cbr\u003e11.3.5 Physicochemical Characteristics of the Drug \u003cbr\u003e11.4 Toxicity \u003cbr\u003e11.5 General Considerations about Polymers used in Nasal Drug Delivery \u003cbr\u003e11.5.1 Thermoresponsive Polymers \u003cbr\u003e11.5.2 Polymers Sensitive to pH \u003cbr\u003e11.5.3 Mucoadhesive Polymer \u003cbr\u003e11.6 Polymers used in Nasal Drug Delivery \u003cbr\u003e11.6.1 Cellulose Derivatives \u003cbr\u003e11.6.2 Polyacrylates \u003cbr\u003e11.6.3 Starch \u003cbr\u003e11.6.4 Chitosan \u003cbr\u003e11.6.5 Gelatin\u003cbr\u003e11.6.6 Phospholipids \u003cbr\u003e11.6.7 Poly(N-alkyl acrylamide)\/Poly(N-isopropylacrylamide) \u003cbr\u003e11.6.8 Poloxamer\u003cbr\u003e11.6.9 Methylcellulose\u003cbr\u003e11.6.10 Cyclodextrin \u003cbr\u003e11.7 Applications of Polymers in Nasal Delivery\u003cbr\u003e11.7.1 Local Therapeutic Agents \u003cbr\u003e11.7.2 Genomics \u003cbr\u003e11.7.3 Proteins and Peptides \u003cbr\u003e11.7.4 Vaccines \u003cbr\u003e11.7.4.1 Features of the Nasal Mucosa for Immunisation \u003cbr\u003e11.8 Conclusion \u003cbr\u003e12 Application of Polymers in Lung Drug Delivery\u003cbr\u003e12.1 Introduction \u003cbr\u003e12.2 Anatomy and Physiology of Human Respiratory Tract\u003cbr\u003e12.3 Barriers in Pulmonary Delivery\u003cbr\u003e12.4 Polymers for Pulmonary Drug Delivery\u003cbr\u003e12.4.1 Natural Polymers \u003cbr\u003e12.4.1.1 Chitosan\u003cbr\u003e12.4.1.2 Gelatin \u003cbr\u003e12.4.1.3 Hyaluronic Acid \u003cbr\u003e12.4.1.4 Dextran\u003cbr\u003e12.4.1.5 Albumin\u003cbr\u003e12.4.2 Synthetic Polymers\u003cbr\u003e12.4.2.1 Poly(D,L-lactide-co-glycolide) \u003cbr\u003e12.4.2.2 Polylactic Acid \u003cbr\u003e12.4.2.3 Poly(?-caprolactone) \u003cbr\u003e12.4.2.4 Acrylic Acid Derivatives\u003cbr\u003e12.4.2.5 Diketopiperazine Derivatives \u003cbr\u003e12.4.2.6 Polyethylene Glycol Conjugates \u003cbr\u003e12.4.3 Miscellaneous Polymers \u003cbr\u003e12.5 Conclusion \u003cbr\u003e12.6 Future Directions \u003cbr\u003e\u003cbr\u003e13 Applications of Polymers in Ocular Drug Delivery\u003cbr\u003e13. 1 Introduction \u003cbr\u003e13.2 Barriers to Restrict Intraocular Drug Transport \u003cbr\u003e13.3 Drug Delivery Systems to the Anterior Segment of the Eye \u003cbr\u003e13.3.1 Viscous Systems\u003cbr\u003e13.3.2 In Situ Gelling Systems \u003cbr\u003e13.3.2.1 Temperature Induced In Situ Gelling Systems \u003cbr\u003e13.3.2.1.1 Poloxamers\u003cbr\u003e13.3.2.1.2 Xyloglucan \u003cbr\u003e13.3.2.1.3 Methyl Cellulose \u003cbr\u003e13.3.2.2 Ionic Strength Induced In Situ Gelling Systems \u003cbr\u003e13.3.2.2.1 Gellan Gum \u003cbr\u003e13.3.2.2.2 Alginates \u003cbr\u003e13.3.2.2.3 Carrageenan \u003cbr\u003e13.3.2.3 pH Induced In Situ Gelling Systems \u003cbr\u003e13.3.2.3.1 Carbomers (Polyacrylic Acid) \u003cbr\u003e13.3.2.3.2 Pseudolatexes \u003cbr\u003e13.3.3 Mucoadhesive Gels \u003cbr\u003e13.3.4 Polymeric Inserts\/Discs \u003cbr\u003e13.3.5 Contact Lenses\u003cbr\u003e13.3.5.1 Conventional Contact Lens Absorbed with Drugs \u003cbr\u003e13.3.5.2 Molecularly Imprinted Polymeric Hydrogels\u003cbr\u003e13.3.5.3 Drug-polymer Films Integrated with Contact Lenses \u003cbr\u003e13.3.5.4 Drugs in Colloidal Structure Dispersed in the Lens \u003cbr\u003e13.3.6 Scleral Lens Delivery Systems \u003cbr\u003e13.3.7 Punctal Plug Delivery Systems \u003cbr\u003e13.4 Polymeric Drug Delivery Systems for the Posterior Segment of the Eye \u003cbr\u003e13.4.1 Intravitreal Implants \u003cbr\u003e13.4.2 Particulate Systems (Nanocarriers) \u003cbr\u003e13.5 Conclusion \u003cbr\u003eAbbreviations \u003cbr\u003eAppendix 1 \u003cbr\u003eAppendix 2 \u003cbr\u003eIndex","published_at":"2017-06-22T21:14:46-04:00","created_at":"2017-06-22T21:14:46-04:00","vendor":"Chemtec Publishing","type":"Book","tags":["2014","book","delivery system","drug absorption","drug delivery","gastric drug delivery","mucaodhesive drug delivery","ocular drug delivery","oral drug delivery","p-applications","patch delivery system","polymer","polymeric system","r-formulation","transdermal drug delivery"],"price":25000,"price_min":25000,"price_max":25000,"available":true,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":43378436164,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Applications of Polymers in Drug Delivery","public_title":null,"options":["Default Title"],"price":25000,"weight":1000,"compare_at_price":null,"inventory_quantity":0,"inventory_management":null,"inventory_policy":"continue","barcode":"9781847358516","requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/chemtec.org\/cdn\/shop\/products\/9781847358516.jpg?v=1498190693"],"featured_image":"\/\/chemtec.org\/cdn\/shop\/products\/9781847358516.jpg?v=1498190693","options":["Title"],"media":[{"alt":null,"id":350156095581,"position":1,"preview_image":{"aspect_ratio":0.767,"height":450,"width":345,"src":"\/\/chemtec.org\/cdn\/shop\/products\/9781847358516.jpg?v=1498190693"},"aspect_ratio":0.767,"height":450,"media_type":"image","src":"\/\/chemtec.org\/cdn\/shop\/products\/9781847358516.jpg?v=1498190693","width":345}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch5\u003eDescription\u003c\/h5\u003e\nAuthor: Edited by Ambikanandan Misra and Aliasgar Shahiwala \u003cbr\u003eISBN 9781847358516 \u003cbr\u003e\u003cbr\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cspan\u003ePublished: 2014\u003cbr\u003e\u003c\/span\u003epage 546\n\u003ch5\u003eSummary\u003c\/h5\u003e\nUse of polymers has become indispensable in the field of drug delivery. Polymers play a crucial role in modulating drug delivery to exploit maximum therapeutic benefits and have been fundamental in the successful development of several novel drug delivery systems that are now available. \u003cbr\u003e\u003cbr\u003eThis book provides details of the applications of polymeric drug delivery systems that will be of interest to researchers in industries and academia. It describes the development of polymeric systems ranging from the conventional dosage forms up to the most recent smart systems. The regulatory and intellectual property aspects, as well as the clinical applicability of polymeric drug delivery systems, are also discussed.\u003cbr\u003e\u003cbr\u003eEach different drug delivery route is discussed in a separate chapter of the book. All major routes of drug delivery have been covered to provide the reader with a panoramic as well as an in-depth view of the developments in polymer-based drug delivery systems. Appendices are included which incorporate useful pharmaceutical properties of the polymers and important polymeric applications for various drug delivery routes.\n\u003ch5\u003eTable of Contents\u003c\/h5\u003e\n1 Polymers in Drug Delivery Systems \u003cbr\u003e1.1 Introduction \u003cbr\u003e1.2 Fundamentals of a Polymeric Drug Delivery System \u003cbr\u003e1.2.1 Factors That Affect Drug Release from Polymers \u003cbr\u003e1.2.2 Mechanism of Controlled Release \u003cbr\u003e1.2.2.1 Temporal Controlled Systems \u003cbr\u003e1.2.2.1.1 Delayed Dissolution \u003cbr\u003e1.2.2.1.2 Diffusion Controlled \u003cbr\u003e1.2.2.1.2.1 Release from Monolithic\/Matrix Systems \u003cbr\u003e1.2.2.1.2.2 Reservoir Type Systems \u003cbr\u003e1.2.2.1.3 Osmotic\/Solvent Controlled Systems \u003cbr\u003e1.2.2.1.4 Swelling Controlled \u003cbr\u003e1.2.2.1.5 Environmental\/Stimuli Responsive Systems \u003cbr\u003e1.2.2.1.5.1 Thermo-responsive Polymers \u003cbr\u003e1.2.2.1.5.2 pH-Responsive Polymers \u003cbr\u003e1.2.2.1.5.3 Dual Stimuli-Responsive Polymers \u003cbr\u003e1.2.2.2 Distribution Controlled Systems \u003cbr\u003e1.2.2.3 Biodegradable\/Degradation and Erosion Controlled Systems \u003cbr\u003e1.3 Polymer Delivery Systems \u003cbr\u003e1.3.1 Oral Drug Delivery System \u003cbr\u003e1.3.1.1 Gastro Retentive Drug Delivery System \u003cbr\u003e1.3.1.1.1 Floating System \u003cbr\u003e1.3.1.1.2 Hydrodynamically Balanced Systems \u003cbr\u003e1.3.1.1.3 Bio\/Mucoadhesive Systems \u003cbr\u003e1.3.1.1.4 Hydration-mediated Adhesion \u003cbr\u003e1.3.1.1.5 Swelling Systems \u003cbr\u003e1.3.1.2 Colon Specific Drug Delivery System \u003cbr\u003e1.3.1.2.1 pH Sensitive Systems \u003cbr\u003e1.3.1.2.1.1 Coating with pH Dependent Polymers\u003cbr\u003e1.3.1.2.1.2 Coating with pH Independent Biodegradable Polymers \u003cbr\u003e1.3.1.2.2 Time Controlled\/Dependent System \u003cbr\u003e1.3.1.2.3 Pressure Controlled System\u003cbr\u003e1.3.1.2.4 Osmotically Controlled System \u003cbr\u003e1.3.1.2.5 Pulsatile Drug Delivery System \u003cbr\u003e1.3.1.3 Ion-exchange Based Drug Delivery System \u003cbr\u003e1.3.2 Transdermal Drug Delivery System \u003cbr\u003e1.3.2.1 Classification of Transdermal Drug Delivery \u003cbr\u003e1.3.2.1.1 Reservoir Systems \u003cbr\u003e1.3.2.1.2 Drug-in-adhesive Systems \u003cbr\u003e1.3.2.1.3 Matrix-dispersion Systems \u003cbr\u003e1.3.2.1.4 Micro-reservoir Systems \u003cbr\u003e1.3.2.2 Polymers for Transdermal Drug Delivery System \u003cbr\u003e1.3.2.2.1 Natural Polymers \u003cbr\u003e1.3.2.2.2 Synthetic Polymers \u003cbr\u003e1.3.2.2.2.1 Pressure Sensitive Adhesives \u003cbr\u003e1.3.2.2.2.2 Backing Membrane \u003cbr\u003e1.3.2.2.2.3 Release Liner \u003cbr\u003e1.3.3 Mucoadhesive Drug Delivery System \u003cbr\u003e1.3.3.1 Hydrophilic Polymers \u003cbr\u003e1.3.3.2 Hydrogels \u003cbr\u003e1.3.3.3 Thiolated Polymers \u003cbr\u003e1.3.3.4 Lectin-based Polymers \u003cbr\u003e1.3.4 Ocular Drug Delivery System \u003cbr\u003e1.3.4.1 Polymers used in Conventional Ocular Delivery \u003cbr\u003e1.3.4.1.1 Liquid Dosage Forms \u003cbr\u003e1.3.4.1.2 Semi-solid Dosage Forms \u003cbr\u003e1.3.4.2 Polymers used in Ophthalmic Inserts\/Films \u003cbr\u003e1.3.5 Implant and Parenteral Drug Delivery System\u003cbr\u003e1.3.5.1 Surgical Implants \u003cbr\u003e1.3.5.2 Microspheres\u003cbr\u003e1.3.5.2.1 Bioadhesive Microspheres \u003cbr\u003e1.3.5.2.2 Floating Microspheres \u003cbr\u003e1.3.5.2.3 Polymeric Microspheres \u003cbr\u003e1.3.5.2.3.1 Biodegradable Polymeric Microspheres \u003cbr\u003e1.3.5.2.3.2 Synthetic Polymeric Microspheres\u003cbr\u003e1.3.5.3 Injectable In Situ Gel \u003cbr\u003e1.3.5.3.1 Thermoplastic Paste \u003cbr\u003e1.3.5.3.2 In Situ Crosslinking System \u003cbr\u003e1.3.5.3.3 In Situ Polymer Precipitation\u003cbr\u003e1.3.5.3.4 Thermally-induced Gelling \u003cbr\u003e1.4 Recent Advancements in Polymer Architecture and Drug Delivery\u003cbr\u003e1.4.1 Block Copolymers \u003cbr\u003e1.4.2 Polymersomes\u003cbr\u003e1.4.3 Hyperbranched Polymers \u003cbr\u003e1.4.4 Graft Polymers \u003cbr\u003e1.4.5 Star Polymers \u003cbr\u003e1.4.6 Dendrimers \u003cbr\u003e1.5 Recent Patent Trends in Polymeric Drug Delivery\u003cbr\u003e1.6 Future Developments \u003cbr\u003e\u003cbr\u003e2 Applications of Polymers in Buccal Drug Delivery \u003cbr\u003e2.1 Introduction \u003cbr\u003e2.1.1 Advantages of Buccal Drug Delivery \u003cbr\u003e2.1.2 Disadvantages of Buccal Drug Delivery \u003cbr\u003e2.2 Factors Affecting Bioadhesion in the Oral Cavity \u003cbr\u003e2.2.1 Functional Groups2\u003cbr\u003e2.2.2 Molecular Weight \u003cbr\u003e2.2.3 Flexibility \u003cbr\u003e2.2.4 Crosslinking Density \u003cbr\u003e2.2.5 Charge\u003cbr\u003e2.2.6 Concentration \u003cbr\u003e2.2.7 Hydration (Swelling) \u003cbr\u003e2.2.8 Environmental Factors\u003cbr\u003e2.3 Buccal Polymeric Dosage Forms \u003cbr\u003e2.3.1 Semi-solids \u003cbr\u003e2.3.2 Solids\u003cbr\u003e2.3.2.1 Powder Dosage Forms\u003cbr\u003e2.3.2.2 Tablets \u003cbr\u003e2.3.2.3 Polymeric Films and Patches \u003cbr\u003e2.4 Novel Carriers \u003cbr\u003e2.5 Conclusions \u003cbr\u003e\u003cbr\u003e3 Applications of Polymers in Gastric Drug Delivery \u003cbr\u003e3.1 Introduction \u003cbr\u003e3.2 Need for Gastric Retention \u003cbr\u003e3.3 Benefits and Pitfalls\u003cbr\u003e3.4 Gastrointestinal Tract \u003cbr\u003e3.4.1 Anatomy of the Gastrointestinal Tract \u003cbr\u003e3.4.1.1 Mucus Layer\u003cbr\u003e3.4.2 Basic Gastrointestinal Tract Physiology \u003cbr\u003e3.5 Factors Affecting Gastric Retention \u003cbr\u003e3.6 Polymers in Gastro Retentive Drug Delivery Systems \u003cbr\u003e3.6.1 Cellulosic Hydrocolloids\u003cbr\u003e3.6.2 Carbomers or Carbopol® \u003cbr\u003e3.6.3 Xanthan Gum\u003cbr\u003e3.6.4 Guar Gum \u003cbr\u003e3.6.5 Chitosan\u003cbr\u003e3.6.6 Eudragit® Polymers\u003cbr\u003e3.6.7 Alginate Polymers \u003cbr\u003e3.6.8 Lectin-based Polymers\u003cbr\u003e3.6.9 Thiolated Polymers \u003cbr\u003e3.6.10 Miscellaneous Polymers\u003cbr\u003e3.7 Evaluation of Gastro Retentive Drug Delivery Systems \u003cbr\u003e3.7.1 In Vitro Evaluation\u003cbr\u003e3.7.1.1 Floating Systems\u003cbr\u003e3.7.1.2 Swelling Systems \u003cbr\u003e3.7.2 In Vitro Release \u003cbr\u003e3.7.3 In Vivo Evaluation \u003cbr\u003e3.8 Application of Polymers in Gastric Delivery Systems \u003cbr\u003e3.8.1 Floating Drug Delivery System\u003cbr\u003e3.8.1.1 Effervescent Floating Dosage Forms \u003cbr\u003e3.8.1.2 Non-effervescent Floating Dosage Forms \u003cbr\u003e3.8.2 Bioadhesive Drug Delivery System \u003cbr\u003e3.8.3 Swelling and Expanding Delivery System \u003cbr\u003e3.8.4 Combinational\/Amalgamative Delivery System\u003cbr\u003e3.8.4.1 Bioadhesive and Floating Approach\u003cbr\u003e3.8.4.2 Swellable and Floating Approach\u003cbr\u003e3.8.4.3 Bioadhesion and Swelling Approach \u003cbr\u003e3.8.4.4 Bioadhesion and High-density Approach\u003cbr\u003e3.8.5 Microparticulate Delivery System\u003cbr\u003e3.8.5.1 Microballoons\/Hollow Microspheres\u003cbr\u003e3.8.5.2 Alginate Beads\u003cbr\u003e3.8.5.3 Floating Granules \u003cbr\u003e3.8.5.4 Super Porous Hydrogel Systems \u003cbr\u003e3.8.5.5 Raft Forming Systems \u003cbr\u003e3.9 Conclusion \u003cbr\u003e4 Applications of Polymers in Small Intestinal Drug Deliver\u003cbr\u003e4.1 Introduction \u003cbr\u003e4.1.1 Advantages of Polymer Coating \u003cbr\u003e4.1.2 Benefit from Polymer Coatings with Sustained Release \u003cbr\u003e4.2 Physiology of the Small Intestine\u003cbr\u003e4.2.1 Mucosa of Small Intestine\u003cbr\u003e4.2.2 Secretion into the Small Intestine\u003cbr\u003e4.2.2.1 Glands\u003cbr\u003e4.2.2.2 Pancreatic Secretion \u003cbr\u003e4.2.2.3 Biliary Secretions\u003cbr\u003e4.2.2.4 Digestion of the Food Nutrients \u003cbr\u003e4.2.3 pH of the Small Intestine\u003cbr\u003e4.2.4 Gastrointestinal Motility \u003cbr\u003e4.2.5 Transit of the Dosage Form through the Small Intestine \u003cbr\u003e4.2.6 Drug Absorption through Small Intestine \u003cbr\u003e4.2.7 Peyer’s Patch \u003cbr\u003e4.3 Scope of Small Intestinal Drug Delivery \u003cbr\u003e4.4 Polymers used in Small Intestinal Drug Delivery\u003cbr\u003e4.4.1 Natural Polymers \u003cbr\u003e4.4.1.1 Chitosan \u003cbr\u003e4.4.1.2 Shellac\u003cbr\u003e4.4.1.3 Sodium Alginate \u003cbr\u003e4.4.2 Synthetic Polymers \u003cbr\u003e4.4.2.1 Polyacrylic acid Derivatives (Carbomer) \u003cbr\u003e4.4.2.2 Cellulose Derivatives \u003cbr\u003e4.4.2.2.1 Cellulose Acetate Phthalate \u003cbr\u003e4.4.2.2.2 Hydroxypropyl Methyl Cellulose Phthalate \u003cbr\u003e4.4.2.2.3 Polyvinyl Acetate Phthalate\u003cbr\u003e4.4.2.2.4 Hydroxypropyl Methyl Cellulose Acetate Succinate\u003cbr\u003e4.4.2.2.5 Cellulose Acetate Trimelliate\u003cbr\u003e4.4.2.3 Polymethacrylates \u003cbr\u003e4.4.2.3.1 Polymethacrylic Acid-co-ethyl Acrylate as Aqueous Dispersion. \u003cbr\u003e4.4.2.3.2 Polymethacrylic Acid-co-ethyl Acrylate as Powder\u003cbr\u003e4.4.2.3.3 Polyethyl Acrylate-co-methyl Methacrylate-co-trimethylammonioethyl Methacrylate Chloride\u003cbr\u003e4.4.2.3.4 Polymethacrylic Acid-co-methyl Methacrylate\u003cbr\u003e4.4.2.3.5 Polymethacrylic Acid-co-methylmethacrylate \u003cbr\u003e4.4.2.3.5.1 Methacrylic Acid - Methyl Methacrylate Copolymer (1:2)\u003cbr\u003e4.4.2.3.5.2 Polymethacrylic Acid-co-methyl Methacrylate (1:2) \u003cbr\u003e4.5 Benefits of Polymers in Small Intestinal Drug Delivery \u003cbr\u003e4.5.1 Hydroxypropyl Methyl Cellulose Phthalate\u003cbr\u003e4.5.2 Hydroxypropyl Methyl Cellulose Acetate Succinate. \u003cbr\u003e4.5.3 Hydroxypropyl Methyl Cellulose Acetate Maleate. \u003cbr\u003e4.5.4 Methacrylic Acid Polymers and Copolymers \u003cbr\u003e4.5.5 Chitosan \u003cbr\u003e4.5.6 Chitosan and Methacrylic Acid Polymer and Copolymers\u003cbr\u003e4.5.7 Sodium Alginate \u003cbr\u003e4.5.8 Thiolated Tamarind Seed Polysaccharide\u003cbr\u003e4.6 Conclusion \u003cbr\u003e\u003cbr\u003e5 Application of Polymers in Transdermal Drug Delivery\u003cbr\u003e5.1 Introduction \u003cbr\u003e5.2 Advantages of Drug Delivery via the Transdermal Route \u003cbr\u003e5.3 Mechanism of Drug Absorption in Transdermal Drug Delivery \u003cbr\u003eSystems\u003cbr\u003e5.4 Factors Affecting Transdermal Permeation\u003cbr\u003e5.4.1 Physicochemical Properties of Penetrant Molecules \u003cbr\u003e5.4.2 Physicochemical Properties of the Drug Delivery \u003cbr\u003eSystem\u003cbr\u003e5.4.2.1 Release Characteristics\u003cbr\u003e5.4.2.2 Composition of the Drug Delivery Systems\u003cbr\u003e5.4.2.3 Drug Permeation Enhancer \u003cbr\u003e5.4.3 Physiological and Pathological Conditions of the Skin\u003cbr\u003e5.5 Types of Transdermal Drug Delivery Systems\u003cbr\u003e5.5.1 Formulation Aspects\u003cbr\u003e5.5.1.1 Matrix Systems \u003cbr\u003e5.5.1.2 Reservoir Systems \u003cbr\u003e5.5.1.3 Micro-reservoir Systems\u003cbr\u003e5.5.2 Based on Release Mechanism\u003cbr\u003e5.5.2.1 Passive Transdermal Drug Delivery Systems. \u003cbr\u003e5.5.2.2 Active Transdermal Drug Delivery Systems \u003cbr\u003e5.6 Role of Polymers in Transdermal Drug Delivery Systems \u003cbr\u003e5.6.1 Matrix Formers\u003cbr\u003e5.6.1.1 Crosslinked Polyethylene Glycol \u003cbr\u003e5.6.1.2 Acrylic-acid Matrices\u003cbr\u003e5.6.1.3 Ethyl Cellulose and Polyvinyl Pyrrolidone \u003cbr\u003e5.6.1.4 Hydroxypropyl Methylcellulose \u003cbr\u003e5.6.1.5 Chitosan \u003cbr\u003e5.6.1.6 Ethyl Vinyl Acetate Copolymer \u003cbr\u003e5.6.1.7 Gum Copal\u003cbr\u003e5.6.1.8 Damar Batu \u003cbr\u003e5.6.1.9 Organogels \u003cbr\u003e5.6.2 Rate-controlling Membrane\u003cbr\u003e5.6.2.1 Ethylene Vinyl Acetate Copolymer \u003cbr\u003e5.6.2.2 Polyethylene \u003cbr\u003e5.6.2.3 Polyurethane\u003cbr\u003e5.6.2.4 Crosslinked Sodium Alginate\u003cbr\u003e5.6.2.5 Copolymer of 2-Hydroxy-3- Phenoxypropylacrylate, 4-Hydroxybutyl Acrylate and Sec-Butyl Tiglate\u003cbr\u003e5.6.2.6 Polysulfone, Polyvinylidene Fluoride (Hydrophilic Membrane)\u003cbr\u003e5.6.2.7 Polytetrafluoroethylene (Hydrophobic Membrane) \u003cbr\u003e5.6.2.8 Crosslinked Polyvinyl Alcohol \u003cbr\u003e5.6.2.9 Cellulose Acetate \u003cbr\u003e5.6.2.10 Eudragit® \u003cbr\u003e5.6.2.11 Chitosan \u003cbr\u003e5.6.3 Pressure Sensitive Adhesives \u003cbr\u003e5.6.3.1 Polyisobutylenes \u003cbr\u003e5.6.3.2 Silicones\u003cbr\u003e5.6.3.3 Acrylics \u003cbr\u003e5.6.3.4 Hot-melt Pressure Sensitive Adhesives \u003cbr\u003e5.6.3.5 Hydrogel Pressure Sensitive Adhesives\u003cbr\u003e5.6.3.6 Hydrophilic Pressure Sensitive Adhesives \u003cbr\u003e5.6.3.7 Polyurethanes \u003cbr\u003e5.6.4 Backing Layer\/Membranes\u003cbr\u003e5.6.5 Release Liner \u003cbr\u003e5.6.6 Polymers to Enhance Skin Permeation\u003cbr\u003e5.6.6.1 Penetration Enhancers\u003cbr\u003e5.6.6.2 Pulsed Delivery \u003cbr\u003e5.7 Future Perspectives\u003cbr\u003e5.8 Conclusion \u003cbr\u003e\u003cbr\u003e6 Application of Polymers in Peyer’s Patch Targeting \u003cbr\u003e6.1 Introduction \u003cbr\u003e6.2 Peyer’s Patch Physiology, Structure, and Function \u003cbr\u003e6.2.1 General Properties and Peyer’s Patch Distribution in Different Species \u003cbr\u003e6.2.2 M Cell Structure and Function\u003cbr\u003e6.3 Strategies for Achieving Effective Delivery to the Peyer’s Patch \u003cbr\u003e6.3.1 General Principles of Peyer’s Patch Delivery\u003cbr\u003e6.3.2 Effect of Particle Size on Peyer’s Patch \u003cbr\u003e6.4 Peyer’s Patch Drug Delivery using Polymeric Carriers\u003cbr\u003e6.4.1 Polylactide-co-glycolic Acid \u003cbr\u003e6.4.2 Polylactic Acid \u003cbr\u003e6.4.3 Poly-D,L-lactide-co-glycolide \u003cbr\u003e6.4.4 Polystyrene \u003cbr\u003e6.4.5 Chitosan \u003cbr\u003e6.4.6 Other Polymer Carrier\u003cbr\u003e6.5 Uptake of Particles by Peyer’s Patches\u003cbr\u003e6.6 Targets for Peyer’s Patch Delivery \u003cbr\u003e6.6.1 Lectin-mediated Targeting \u003cbr\u003e6.6.2 Microbial Protein-mediated Targeting \u003cbr\u003e6.6.2.1 Yersinia \u003cbr\u003e6.6.2.2 Salmonella \u003cbr\u003e6.6.2.3 Cholera Toxin \u003cbr\u003e6.6.2.4 Virus Protein \u003cbr\u003e6.6.3 Vitamin B12 Mediated Targeting\u003cbr\u003e6.6.4 Non-Peptide Ligand Mediated Targeting \u003cbr\u003e6.6.5 Peptide Ligand Mediated Targeting \u003cbr\u003e6.6.6 Claudin-4 Mediated Targeting \u003cbr\u003e6.6.7 Monoclonal Antibody Mediated Targeting \u003cbr\u003e6.6.8 M Cell Homing Peptide Targeting \u003cbr\u003e6.6.9 Immunoglobulin A Conjugates Targeting\u003cbr\u003e6.7 Summary and Conclusions \u003cbr\u003e7 Applications of Polymers in Colon Drug Delivery \u003cbr\u003e7.1 Introduction \u003cbr\u003e7.2 Anatomy of the Colon \u003cbr\u003e7.3 Correlation between Physiological Factors and use of Polymers in Colon Drug Delivery Systems\u003cbr\u003e7.3.1 The pH of the Gastrointestinal Tract \u003cbr\u003e7.3.2 Gastrointestinal Transit Time \u003cbr\u003e7.3.3 Colonic Motility \u003cbr\u003e7.3.4 Colonic Microflora\u003cbr\u003e7.3.5 Colonic Absorption\u003cbr\u003e7.4 Advantages of Colon Drug Delivery Systems\u003cbr\u003e7.5 Disadvantages of Colon Drug Delivery Systems \u003cbr\u003e7.6 Polymers for Colon Drug Delivery Systems \u003cbr\u003e7.6.1 Pectin\u003cbr\u003e7.6.2 Guar Gum \u003cbr\u003e7.6.3 Chitosan \u003cbr\u003e7.6.4 Amylose \u003cbr\u003e7.6.5 Inulin \u003cbr\u003e7.6.6 Locust Bean Gum \u003cbr\u003e7.6.7 Chondroitin Sulfate \u003cbr\u003e7.6.8 Dextran \u003cbr\u003e7.6.9 Alginates \u003cbr\u003e7.6.10 Cyclodextrin \u003cbr\u003e7.6.11 Eudragit® \u003cbr\u003e7.6.12 Cellulose Ethers \u003cbr\u003e7.6.13 Ethyl Cellulose\u003cbr\u003e7.6.14 Polymers for Enteric Coating\u003cbr\u003e7.6.15 Polyvinyl Alcohol \u003cbr\u003e7.7 Application of Polymers in Colon Drug Delivery Systems\u003cbr\u003e7.7.1 System Dependent on pH \u003cbr\u003e7.7.2 System Dependent on Time\u003cbr\u003e7.7.2.1 Reservoir Systems with Rupturable Polymeric Coats \u003cbr\u003e7.7.2.2 Reservoir Systems with Erodible Polymeric Coats \u003cbr\u003e7.7.2.3 Reservoir Systems with Diffusive Polymeric Coats \u003cbr\u003e7.7.2.4 Capsular Systems with Release-controlling Polymeric Plugs \u003cbr\u003e7.7.2.5 Osmotic System \u003cbr\u003e7.7.3 Bacterially Triggered System \u003cbr\u003e7.7.3.1 Prodrug \u003cbr\u003e7.7.3.2 Polysaccharide-based Matrix, Reservoirs and Hydrogels\u003cbr\u003e7.7.4 Time- and pH-Dependent Systems \u003cbr\u003e7.7.5 Pressure Controlled Delivery Systems \u003cbr\u003e7.8 Conclusion\u003cbr\u003e\u003cbr\u003e8 Applications of Polymers in Parenteral Drug Delivery \u003cbr\u003e8.1 Introduction \u003cbr\u003e8.2 Parenteral Route for Drug Delivery\u003cbr\u003e8.2.1 Advantages of Parenteral Administration \u003cbr\u003e8.2.2 Disadvantages of Parenteral Administration\u003cbr\u003e8.3 In Vivo Distribution of Polymer \u003cbr\u003e8.4 Biodegradation\u003cbr\u003e8.4.1 Erosion \u003cbr\u003e8.4.2 Degradation Processes\u003cbr\u003e8.4.2.1 Chemical and Enzymic Oxidation \u003cbr\u003e8.4.2.2 Chemical and Enzymic Hydrolysis \u003cbr\u003e8.5 Polymers for Parenteral Delivery \u003cbr\u003e8.5.1 Non-degradable Polymers\u003cbr\u003e8.5.2 Biodegradable Polymers \u003cbr\u003e8.5.2.1 Synthetic Polymers \u003cbr\u003e8.5.2.1.1 Polyesters \u003cbr\u003e8.5.2.1.2 Polylactones \u003cbr\u003e8.5.2.1.3 Polyamino acids \u003cbr\u003e8.5.2.1.4 Polyphosphazenes \u003cbr\u003e8.5.2.1.5 Polyorthoesters \u003cbr\u003e8.5.2.1.6 Polyanhydrides \u003cbr\u003e8.5.2.2 Natural Polymers \u003cbr\u003e8.5.2.2.1 Collagen \u003cbr\u003e8.5.2.2.2 Gelatin \u003cbr\u003e8.5.2.2.3 Albumin \u003cbr\u003e8.5.2.2.4 Polysaccharides \u003cbr\u003e8.6 Polymeric Drug Delivery Carriers\u003cbr\u003e8.6.1 Polymeric Implants \u003cbr\u003e8.6.2 Microparticles \u003cbr\u003e8.6.3 Nanoparticles \u003cbr\u003e8.6.4 Polymeric Micelles \u003cbr\u003e8.6.5 Hydrogels \u003cbr\u003e8.6.6 Polymer-drug Conjugates \u003cbr\u003e8.7 Factors Influencing Polymeric Parenteral Delivery\u003cbr\u003e8.7.1 Particle Size \u003cbr\u003e8.7.2 Drug Loading \u003cbr\u003e8.7.3 Porosity \u003cbr\u003e8.7.4 Molecular Weight of the Polymer \u003cbr\u003e8.7.5 Crystallinity\u003cbr\u003e8.7.6 Hydrophobicity\u003cbr\u003e8.7.7 Drug-polymer Interactions \u003cbr\u003e8.7.8 Surface Properties: Charge and Modifications \u003cbr\u003e8.8 Summary \u003cbr\u003e\u003cbr\u003e9 Applications of Polymers in Rectal Drug Delivery\u003cbr\u003e9.1 Introduction \u003cbr\u003e9.2 Rectal Drug Delivery\u003cbr\u003e9.2.1 Anatomy and Physiology of the Rectum \u003cbr\u003e9.2.2 Absorption through the Rectum\u003cbr\u003e9.2.2.1 Mechanism of Absorption\u003cbr\u003e9.2.2.2 Factors Affecting Absorption\u003cbr\u003e9.3 Polymers used in Rectal Dosage Forms\u003cbr\u003e9.3.1 Solutions \u003cbr\u003e9.3.2 Semi-solids\/Hydrogels \u003cbr\u003e9.3.3 Suppositories \u003cbr\u003e9.3.4 In Situ Gels \u003cbr\u003e9.4 Conclusion \u003cbr\u003e\u003cbr\u003e10 Applications of Polymers in Vaginal Drug Delivery \u003cbr\u003e10.1 Anatomy and Physiology of the Vagina \u003cbr\u003e10.1.1 Vaginal pH \u003cbr\u003e10.1.2 Vaginal Microflora \u003cbr\u003e10.1.3 Cyclic Changes \u003cbr\u003e10.1.4 Vaginal Blood Supply\u003cbr\u003e10.2 The Vagina as a Site for Drug Delivery \u003cbr\u003e10.3 Vaginal Dosage Forms \u003cbr\u003e10.4 Polymers for Vaginal Drug Delivery \u003cbr\u003e10.4.1 Polyacrylates \u003cbr\u003e10.4.2 Chitosan \u003cbr\u003e10.4.3 Cellulose Derivatives \u003cbr\u003e10.4.4 Hyaluronic Acid Derivatives \u003cbr\u003e10.4.5 Carrageenan \u003cbr\u003e10.4.6 Polyethylene Glycols \u003cbr\u003e10.4.7 Gelatin \u003cbr\u003e10.4.8 Thiomers \u003cbr\u003e10.4.9 Poloxamers \u003cbr\u003e10.4.10 Pectin and Tragacanth \u003cbr\u003e10.4.11 Sodium Alginate \u003cbr\u003e10.4.12 Silicone Elastomers for Vaginal Rings \u003cbr\u003e10.4.13 Thermoplastic Polymers for Vaginal Rings \u003cbr\u003e10.4.14 Miscellaneous \u003cbr\u003e10.5 Toxicological Evaluation\u003cbr\u003e10.6 Conclusion \u003cbr\u003e\u003cbr\u003e11 Application of Polymers in Nasal Drug Delivery\u003cbr\u003e11.1 Introduction 379\u003cbr\u003e11.2 Nasal Anatomy and Physiology \u003cbr\u003e11.2.1 Nasal Vestibule \u003cbr\u003e11.2.2 Atrium \u003cbr\u003e11.2.3 Olfactory Region \u003cbr\u003e11.2.4 Respiratory Region \u003cbr\u003e11.2.5 Nasopharynx\u003cbr\u003e11.3 Biological Barriers in Nasal Absorption \u003cbr\u003e11.3.1 Mucus \u003cbr\u003e11.3.2 Nasal Mucociliary Clearance \u003cbr\u003e11.3.3 Enzymic Barrier\u003cbr\u003e11.3.4 P-Glycoprotein Efflux Transporters\u003cbr\u003e11.3.5 Physicochemical Characteristics of the Drug \u003cbr\u003e11.4 Toxicity \u003cbr\u003e11.5 General Considerations about Polymers used in Nasal Drug Delivery \u003cbr\u003e11.5.1 Thermoresponsive Polymers \u003cbr\u003e11.5.2 Polymers Sensitive to pH \u003cbr\u003e11.5.3 Mucoadhesive Polymer \u003cbr\u003e11.6 Polymers used in Nasal Drug Delivery \u003cbr\u003e11.6.1 Cellulose Derivatives \u003cbr\u003e11.6.2 Polyacrylates \u003cbr\u003e11.6.3 Starch \u003cbr\u003e11.6.4 Chitosan \u003cbr\u003e11.6.5 Gelatin\u003cbr\u003e11.6.6 Phospholipids \u003cbr\u003e11.6.7 Poly(N-alkyl acrylamide)\/Poly(N-isopropylacrylamide) \u003cbr\u003e11.6.8 Poloxamer\u003cbr\u003e11.6.9 Methylcellulose\u003cbr\u003e11.6.10 Cyclodextrin \u003cbr\u003e11.7 Applications of Polymers in Nasal Delivery\u003cbr\u003e11.7.1 Local Therapeutic Agents \u003cbr\u003e11.7.2 Genomics \u003cbr\u003e11.7.3 Proteins and Peptides \u003cbr\u003e11.7.4 Vaccines \u003cbr\u003e11.7.4.1 Features of the Nasal Mucosa for Immunisation \u003cbr\u003e11.8 Conclusion \u003cbr\u003e12 Application of Polymers in Lung Drug Delivery\u003cbr\u003e12.1 Introduction \u003cbr\u003e12.2 Anatomy and Physiology of Human Respiratory Tract\u003cbr\u003e12.3 Barriers in Pulmonary Delivery\u003cbr\u003e12.4 Polymers for Pulmonary Drug Delivery\u003cbr\u003e12.4.1 Natural Polymers \u003cbr\u003e12.4.1.1 Chitosan\u003cbr\u003e12.4.1.2 Gelatin \u003cbr\u003e12.4.1.3 Hyaluronic Acid \u003cbr\u003e12.4.1.4 Dextran\u003cbr\u003e12.4.1.5 Albumin\u003cbr\u003e12.4.2 Synthetic Polymers\u003cbr\u003e12.4.2.1 Poly(D,L-lactide-co-glycolide) \u003cbr\u003e12.4.2.2 Polylactic Acid \u003cbr\u003e12.4.2.3 Poly(?-caprolactone) \u003cbr\u003e12.4.2.4 Acrylic Acid Derivatives\u003cbr\u003e12.4.2.5 Diketopiperazine Derivatives \u003cbr\u003e12.4.2.6 Polyethylene Glycol Conjugates \u003cbr\u003e12.4.3 Miscellaneous Polymers \u003cbr\u003e12.5 Conclusion \u003cbr\u003e12.6 Future Directions \u003cbr\u003e\u003cbr\u003e13 Applications of Polymers in Ocular Drug Delivery\u003cbr\u003e13. 1 Introduction \u003cbr\u003e13.2 Barriers to Restrict Intraocular Drug Transport \u003cbr\u003e13.3 Drug Delivery Systems to the Anterior Segment of the Eye \u003cbr\u003e13.3.1 Viscous Systems\u003cbr\u003e13.3.2 In Situ Gelling Systems \u003cbr\u003e13.3.2.1 Temperature Induced In Situ Gelling Systems \u003cbr\u003e13.3.2.1.1 Poloxamers\u003cbr\u003e13.3.2.1.2 Xyloglucan \u003cbr\u003e13.3.2.1.3 Methyl Cellulose \u003cbr\u003e13.3.2.2 Ionic Strength Induced In Situ Gelling Systems \u003cbr\u003e13.3.2.2.1 Gellan Gum \u003cbr\u003e13.3.2.2.2 Alginates \u003cbr\u003e13.3.2.2.3 Carrageenan \u003cbr\u003e13.3.2.3 pH Induced In Situ Gelling Systems \u003cbr\u003e13.3.2.3.1 Carbomers (Polyacrylic Acid) \u003cbr\u003e13.3.2.3.2 Pseudolatexes \u003cbr\u003e13.3.3 Mucoadhesive Gels \u003cbr\u003e13.3.4 Polymeric Inserts\/Discs \u003cbr\u003e13.3.5 Contact Lenses\u003cbr\u003e13.3.5.1 Conventional Contact Lens Absorbed with Drugs \u003cbr\u003e13.3.5.2 Molecularly Imprinted Polymeric Hydrogels\u003cbr\u003e13.3.5.3 Drug-polymer Films Integrated with Contact Lenses \u003cbr\u003e13.3.5.4 Drugs in Colloidal Structure Dispersed in the Lens \u003cbr\u003e13.3.6 Scleral Lens Delivery Systems \u003cbr\u003e13.3.7 Punctal Plug Delivery Systems \u003cbr\u003e13.4 Polymeric Drug Delivery Systems for the Posterior Segment of the Eye \u003cbr\u003e13.4.1 Intravitreal Implants \u003cbr\u003e13.4.2 Particulate Systems (Nanocarriers) \u003cbr\u003e13.5 Conclusion \u003cbr\u003eAbbreviations \u003cbr\u003eAppendix 1 \u003cbr\u003eAppendix 2 \u003cbr\u003eIndex"}

Biocides in Plastics

$153.00

{"id":11242214020,"title":"Biocides in Plastics","handle":"978-1-85957-512-3","description":"\u003ch5\u003eDescription\u003c\/h5\u003e\nAuthor: D. Nichols, Thor Overseas Limited \u003cbr\u003eISBN 978-1-85957-512-3 \u003cbr\u003e\u003cbr\u003e\n\u003cp\u003ePages: 126\u003cbr\u003eFormat: Soft-backed\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eSummary\u003c\/h5\u003e\nThe use of biocides in plastics is commonplace. They are added to protect the plastic from degradation by microbes or to provide an external antimicrobial hygienic surface.\u003cbr\u003e\u003cbr\u003eBiocides are selected on the basis of their function and the application for which they are intended, but choosing the right biocide is often not so simple. As well as biocidal performance, the in-process stability, migration, leachability, light and heat stability may all be important factors.\u003cbr\u003e\u003cbr\u003eThis Rapra Review Report examines the use of biocides in plastics with reference to material types and application requirements. The commonly available biocides are reviewed and details of their strengths and weaknesses are provided. The author reviews the frequently used test methods for fungi and bacteria, and, in an ever-changing regulatory environment, explores the influence of legislation on the current and future use of such biocides.\u003cbr\u003e\u003cbr\u003eThis report will be of interest to biocide suppliers and plastic product manufacturers, and to all professionals requiring information on biocide chemistry and application.\u003cbr\u003e\u003cbr\u003eThis detailed and state-of-the-art review is supported by an indexed section containing several hundred key references and abstracts selected from the Polymer Library.\u003cbr\u003e\u003cbr\u003e\n\u003ch5\u003eTable of Contents\u003c\/h5\u003e\n\u003cb\u003e1 INTRODUCTION\u003c\/b\u003e\u003cbr\u003e2.1 Bacteria\u003cbr\u003e2.2 Fungi\u003cbr\u003e2.3 Algae\u003cbr\u003e\u003cbr\u003e\u003cb\u003e2 THE NEED FOR BIOCIDES IN PLASTICS AND BASIC MICROBIOLOGY\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003e3 PLASTIC MATERIALS REQUIRING BIOCIDES\u003c\/b\u003e\u003cbr\u003e3.1 Biostabiliser Effects\u003cbr\u003e3.1.1 Nutrient Sources for Fungi and Bacteria\u003cbr\u003e3.1.2 Microbiological Effects\u003cbr\u003e3.1.3 Organisms of Importance\u003cbr\u003e3.2 Hygienic Applications\u003cbr\u003e3.2.1 Organisms of Interest\u003cbr\u003e3.2.2 Merits of Such Biocides\u003cbr\u003e3.2.3 The Bacterial Problem\u003cbr\u003e3.2.4 False Claims\u003cbr\u003e3.2.5 Conclusions Regarding Hygienic Applications\u003cbr\u003e3.3 Active Packaging\u003cbr\u003e\u003cbr\u003e\u003cb\u003e4 TEST METHODS\u003c\/b\u003e\u003cbr\u003e4.1 Fungal Test Methods\u003cbr\u003e4.1.1 Fungicidal Procedures\u003cbr\u003e4.1.2 Fungistatic Procedures\u003cbr\u003e4.1.3 Soil Burial\u003cbr\u003e4.1.4 Humidity Chamber or Vermiculite Bed\u003cbr\u003e4.2 Bacterial Test Methods\u003cbr\u003e4.2.1 Resistance of Plastic to Bacteria\u003cbr\u003e4.2.2 Antimicrobial Plastic\u003cbr\u003e4.2.3 Pink Stain Test\u003cbr\u003e4.3 Laboratory Tests versus use Conditions\u003cbr\u003e\u003cbr\u003e\u003cb\u003e5 AVAILABLE ACTIVE INGREDIENTS\u003c\/b\u003e\u003cbr\u003e5.1 Migratory Biocides\u003cbr\u003e5.1.1 OBPA\u003cbr\u003e5.1.2 OIT\u003cbr\u003e5.1.3 Butyl BIT\u003cbr\u003e5.1.4 Zinc Pyrithione\u003cbr\u003e5.1.5 Iodo-Propylbutyl Carbamate (IPBC)\u003cbr\u003e5.1.6 N-Haloalkylthio Compounds\u003cbr\u003e5.1.7 Carbendazim (N-benzimidazol-2-ylcarbamic acid methylester)\u003cbr\u003e5.1.8 Bethoxazin (3-Benzo(b)thien-2-yl-5,6-dihydro-1,4,2-oxathiazine 4-oxide)\u003cbr\u003e5.2 Non or Low Migratory Biocides\u003cbr\u003e5.2.1 Triclosan (2,2,4-dicholoro-2-hydroxydiphenyl ether)\u003cbr\u003e5.2.2 DCOIT \u003cbr\u003e5.2.3 Silver\u003cbr\u003e5.2.4 Sustainable Antimicrobial Polymers (Degussa)\u003cbr\u003e5.2.5 Titanium Dioxide Nanoparticles\u003cbr\u003e5.3 Other Ingredients\u003cbr\u003e\u003cbr\u003e\u003cb\u003e6 LEGISLATION REGARDING BIOCIDES\u003c\/b\u003e\u003cbr\u003e6.1 Limitations of Use\u003cbr\u003e6.2 Future Requirements\u003cbr\u003e6.3 BPD Exemptions\u003cbr\u003e\u003cbr\u003e\u003cb\u003e7 SUMMARY\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eAdditional References\u003cbr\u003eUnpublished References\u003cbr\u003eBibliography\u003cbr\u003eAcknowledgements\u003cbr\u003eAbbreviations\u003cbr\u003eSubject Index\u003cbr\u003eCompany Index\u003cbr\u003e\u003cbr\u003e\n\u003ch5\u003eAbout Author\u003c\/h5\u003e\nDean Nichols has a BSc. (Hons.) degree in biology and has worked for THOR, a speciality chemicals company and leading biocide company, for the past 15 years. His experience has involved research and development and marketing of biocides and other speciality chemicals to the Middle East, Europe and some countries in the Far East. Currently, he is a member of Thors biocide product management team and has a global role for promotion of products, services and expertise into various market sectors.","published_at":"2017-06-22T21:13:20-04:00","created_at":"2017-06-22T21:13:20-04:00","vendor":"Chemtec Publishing","type":"Book","tags":["2005","Biocides","book","degradation plastics","environment","p-additives","polymer"],"price":15300,"price_min":15300,"price_max":15300,"available":true,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":43378351044,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Biocides in Plastics","public_title":null,"options":["Default Title"],"price":15300,"weight":1000,"compare_at_price":null,"inventory_quantity":0,"inventory_management":null,"inventory_policy":"continue","barcode":"978-1-85957-512-3","requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/chemtec.org\/cdn\/shop\/products\/978-1-85957-512-3.jpg?v=1498191099"],"featured_image":"\/\/chemtec.org\/cdn\/shop\/products\/978-1-85957-512-3.jpg?v=1498191099","options":["Title"],"media":[{"alt":null,"id":350156849245,"position":1,"preview_image":{"aspect_ratio":0.767,"height":450,"width":345,"src":"\/\/chemtec.org\/cdn\/shop\/products\/978-1-85957-512-3.jpg?v=1498191099"},"aspect_ratio":0.767,"height":450,"media_type":"image","src":"\/\/chemtec.org\/cdn\/shop\/products\/978-1-85957-512-3.jpg?v=1498191099","width":345}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch5\u003eDescription\u003c\/h5\u003e\nAuthor: D. Nichols, Thor Overseas Limited \u003cbr\u003eISBN 978-1-85957-512-3 \u003cbr\u003e\u003cbr\u003e\n\u003cp\u003ePages: 126\u003cbr\u003eFormat: Soft-backed\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eSummary\u003c\/h5\u003e\nThe use of biocides in plastics is commonplace. They are added to protect the plastic from degradation by microbes or to provide an external antimicrobial hygienic surface.\u003cbr\u003e\u003cbr\u003eBiocides are selected on the basis of their function and the application for which they are intended, but choosing the right biocide is often not so simple. As well as biocidal performance, the in-process stability, migration, leachability, light and heat stability may all be important factors.\u003cbr\u003e\u003cbr\u003eThis Rapra Review Report examines the use of biocides in plastics with reference to material types and application requirements. The commonly available biocides are reviewed and details of their strengths and weaknesses are provided. The author reviews the frequently used test methods for fungi and bacteria, and, in an ever-changing regulatory environment, explores the influence of legislation on the current and future use of such biocides.\u003cbr\u003e\u003cbr\u003eThis report will be of interest to biocide suppliers and plastic product manufacturers, and to all professionals requiring information on biocide chemistry and application.\u003cbr\u003e\u003cbr\u003eThis detailed and state-of-the-art review is supported by an indexed section containing several hundred key references and abstracts selected from the Polymer Library.\u003cbr\u003e\u003cbr\u003e\n\u003ch5\u003eTable of Contents\u003c\/h5\u003e\n\u003cb\u003e1 INTRODUCTION\u003c\/b\u003e\u003cbr\u003e2.1 Bacteria\u003cbr\u003e2.2 Fungi\u003cbr\u003e2.3 Algae\u003cbr\u003e\u003cbr\u003e\u003cb\u003e2 THE NEED FOR BIOCIDES IN PLASTICS AND BASIC MICROBIOLOGY\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003e3 PLASTIC MATERIALS REQUIRING BIOCIDES\u003c\/b\u003e\u003cbr\u003e3.1 Biostabiliser Effects\u003cbr\u003e3.1.1 Nutrient Sources for Fungi and Bacteria\u003cbr\u003e3.1.2 Microbiological Effects\u003cbr\u003e3.1.3 Organisms of Importance\u003cbr\u003e3.2 Hygienic Applications\u003cbr\u003e3.2.1 Organisms of Interest\u003cbr\u003e3.2.2 Merits of Such Biocides\u003cbr\u003e3.2.3 The Bacterial Problem\u003cbr\u003e3.2.4 False Claims\u003cbr\u003e3.2.5 Conclusions Regarding Hygienic Applications\u003cbr\u003e3.3 Active Packaging\u003cbr\u003e\u003cbr\u003e\u003cb\u003e4 TEST METHODS\u003c\/b\u003e\u003cbr\u003e4.1 Fungal Test Methods\u003cbr\u003e4.1.1 Fungicidal Procedures\u003cbr\u003e4.1.2 Fungistatic Procedures\u003cbr\u003e4.1.3 Soil Burial\u003cbr\u003e4.1.4 Humidity Chamber or Vermiculite Bed\u003cbr\u003e4.2 Bacterial Test Methods\u003cbr\u003e4.2.1 Resistance of Plastic to Bacteria\u003cbr\u003e4.2.2 Antimicrobial Plastic\u003cbr\u003e4.2.3 Pink Stain Test\u003cbr\u003e4.3 Laboratory Tests versus use Conditions\u003cbr\u003e\u003cbr\u003e\u003cb\u003e5 AVAILABLE ACTIVE INGREDIENTS\u003c\/b\u003e\u003cbr\u003e5.1 Migratory Biocides\u003cbr\u003e5.1.1 OBPA\u003cbr\u003e5.1.2 OIT\u003cbr\u003e5.1.3 Butyl BIT\u003cbr\u003e5.1.4 Zinc Pyrithione\u003cbr\u003e5.1.5 Iodo-Propylbutyl Carbamate (IPBC)\u003cbr\u003e5.1.6 N-Haloalkylthio Compounds\u003cbr\u003e5.1.7 Carbendazim (N-benzimidazol-2-ylcarbamic acid methylester)\u003cbr\u003e5.1.8 Bethoxazin (3-Benzo(b)thien-2-yl-5,6-dihydro-1,4,2-oxathiazine 4-oxide)\u003cbr\u003e5.2 Non or Low Migratory Biocides\u003cbr\u003e5.2.1 Triclosan (2,2,4-dicholoro-2-hydroxydiphenyl ether)\u003cbr\u003e5.2.2 DCOIT \u003cbr\u003e5.2.3 Silver\u003cbr\u003e5.2.4 Sustainable Antimicrobial Polymers (Degussa)\u003cbr\u003e5.2.5 Titanium Dioxide Nanoparticles\u003cbr\u003e5.3 Other Ingredients\u003cbr\u003e\u003cbr\u003e\u003cb\u003e6 LEGISLATION REGARDING BIOCIDES\u003c\/b\u003e\u003cbr\u003e6.1 Limitations of Use\u003cbr\u003e6.2 Future Requirements\u003cbr\u003e6.3 BPD Exemptions\u003cbr\u003e\u003cbr\u003e\u003cb\u003e7 SUMMARY\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eAdditional References\u003cbr\u003eUnpublished References\u003cbr\u003eBibliography\u003cbr\u003eAcknowledgements\u003cbr\u003eAbbreviations\u003cbr\u003eSubject Index\u003cbr\u003eCompany Index\u003cbr\u003e\u003cbr\u003e\n\u003ch5\u003eAbout Author\u003c\/h5\u003e\nDean Nichols has a BSc. (Hons.) degree in biology and has worked for THOR, a speciality chemicals company and leading biocide company, for the past 15 years. His experience has involved research and development and marketing of biocides and other speciality chemicals to the Middle East, Europe and some countries in the Far East. Currently, he is a member of Thors biocide product management team and has a global role for promotion of products, services and expertise into various market sectors."}

Biodegradable Polymers

$390.00

{"id":11242213828,"title":"Biodegradable Polymers","handle":"978-1-85957-519-2","description":"\u003ch5\u003eDescription\u003c\/h5\u003e\nAuthor: David K. Platt \u003cbr\u003eISBN 978-1-85957-519-2 \u003cbr\u003e\u003cbr\u003eRapra Market Report\u003cbr\u003e\n\u003ch5\u003eSummary\u003c\/h5\u003e\nBiodegradable polymers have experienced strong growth over the last three years and are set to make further inroads into markets traditionally dominated by conventional thermoplastics in future. \u003cbr\u003e\u003cbr\u003eDemand is being driven by a number of factors. \u003cbr\u003eThe cost of biodegradable polymers has come down considerably over the last three years while at the same time standard thermoplastic prices have increased considerably. Now, some classes of biodegradable polymers are price competitive with polymers such as PET. \u003cbr\u003e\u003cbr\u003eThe biodegradable polymers industry itself has established an agreed framework for testing and certification and there is growing political pressure in developed countries to reduce packaging waste and develop a composting infrastructure. Biodegradable polymer producers have also invested in product and process improvements. Finally, consumers and brand owners are beginning to recognize the benefits of sustainable or ‘green’ packaging. \u003cbr\u003e\u003cbr\u003eFour main classes of biodegradable polymers are analyzed in this report, polylactic acid (PLA), starch-based polymers, synthetic biodegradable polymers, such as aromatic aliphatic co-polyesters, and polyhydroxyalkanoates (PHA). The report analyses their key performance properties, applications development, market drivers and future prospects. Each product section also contains an estimate of market size by world region and end use market, plus forecasts to 2010. There is also an analysis of key suppliers and their products. \u003cbr\u003e\u003cbr\u003e\u003cb\u003eKey Features\u003c\/b\u003e \u003cbr\u003eBiodegradable polymers market size by geographic region, polymer type and end use sector, 2000 and 2005, plus forecasts to 2010. Market opportunity analysis by end use sector, such as packaging, bags and sacks, foodservice, agriculture, medical, consumer products and fibres. Illustrations of product and applications development over the last three years. Supply chain analysis: including details of thirty leading biodegradable polymer suppliers and profiles of around fifty of the world’s leading biodegradable polymer processors. Analysis of biodegradable polymer performance properties, market drivers, applications and product developments.\u003cbr\u003e\u003cbr\u003e\n\u003ch5\u003eAbout Author\u003c\/h5\u003e\nDavid Platt graduated from the University of Nottingham with an Economics degree before completing an MBA at the University of Bradford. He joined a leading international market consultancy where he specialized in plastics sector research. He conducted a wide range of multi-client and single-client studies covering a wide range of materials, from standard thermoplastics, engineering and high performance polymers to conductive polymers and thermoplastic elastomers. Now operating as a freelance consultant, he makes regular contributions to the European plastics trade press, and works with leading plastics industry consultants.","published_at":"2017-06-22T21:13:20-04:00","created_at":"2017-06-22T21:13:20-04:00","vendor":"Chemtec Publishing","type":"Book","tags":["2006","agriculture","analysis","aromatic aliphatic co-polyesters","bags","biodegradable polymers","book","consumer products","foodservice","market","medical","packaging","PHA","PLA","polyhydroxyalkanoates","polylactic acid","polymer","polymers","properties","report","sacks","starch-based polymers","synthetic biodegradable polymers"],"price":39000,"price_min":39000,"price_max":39000,"available":true,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":43378350852,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Biodegradable Polymers","public_title":null,"options":["Default Title"],"price":39000,"weight":1000,"compare_at_price":null,"inventory_quantity":1,"inventory_management":null,"inventory_policy":"continue","barcode":"978-1-85957-519-2","requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/chemtec.org\/cdn\/shop\/products\/978-1-85957-519-2.jpg?v=1498191157"],"featured_image":"\/\/chemtec.org\/cdn\/shop\/products\/978-1-85957-519-2.jpg?v=1498191157","options":["Title"],"media":[{"alt":null,"id":350156882013,"position":1,"preview_image":{"aspect_ratio":0.767,"height":450,"width":345,"src":"\/\/chemtec.org\/cdn\/shop\/products\/978-1-85957-519-2.jpg?v=1498191157"},"aspect_ratio":0.767,"height":450,"media_type":"image","src":"\/\/chemtec.org\/cdn\/shop\/products\/978-1-85957-519-2.jpg?v=1498191157","width":345}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch5\u003eDescription\u003c\/h5\u003e\nAuthor: David K. Platt \u003cbr\u003eISBN 978-1-85957-519-2 \u003cbr\u003e\u003cbr\u003eRapra Market Report\u003cbr\u003e\n\u003ch5\u003eSummary\u003c\/h5\u003e\nBiodegradable polymers have experienced strong growth over the last three years and are set to make further inroads into markets traditionally dominated by conventional thermoplastics in future. \u003cbr\u003e\u003cbr\u003eDemand is being driven by a number of factors. \u003cbr\u003eThe cost of biodegradable polymers has come down considerably over the last three years while at the same time standard thermoplastic prices have increased considerably. Now, some classes of biodegradable polymers are price competitive with polymers such as PET. \u003cbr\u003e\u003cbr\u003eThe biodegradable polymers industry itself has established an agreed framework for testing and certification and there is growing political pressure in developed countries to reduce packaging waste and develop a composting infrastructure. Biodegradable polymer producers have also invested in product and process improvements. Finally, consumers and brand owners are beginning to recognize the benefits of sustainable or ‘green’ packaging. \u003cbr\u003e\u003cbr\u003eFour main classes of biodegradable polymers are analyzed in this report, polylactic acid (PLA), starch-based polymers, synthetic biodegradable polymers, such as aromatic aliphatic co-polyesters, and polyhydroxyalkanoates (PHA). The report analyses their key performance properties, applications development, market drivers and future prospects. Each product section also contains an estimate of market size by world region and end use market, plus forecasts to 2010. There is also an analysis of key suppliers and their products. \u003cbr\u003e\u003cbr\u003e\u003cb\u003eKey Features\u003c\/b\u003e \u003cbr\u003eBiodegradable polymers market size by geographic region, polymer type and end use sector, 2000 and 2005, plus forecasts to 2010. Market opportunity analysis by end use sector, such as packaging, bags and sacks, foodservice, agriculture, medical, consumer products and fibres. Illustrations of product and applications development over the last three years. Supply chain analysis: including details of thirty leading biodegradable polymer suppliers and profiles of around fifty of the world’s leading biodegradable polymer processors. Analysis of biodegradable polymer performance properties, market drivers, applications and product developments.\u003cbr\u003e\u003cbr\u003e\n\u003ch5\u003eAbout Author\u003c\/h5\u003e\nDavid Platt graduated from the University of Nottingham with an Economics degree before completing an MBA at the University of Bradford. He joined a leading international market consultancy where he specialized in plastics sector research. He conducted a wide range of multi-client and single-client studies covering a wide range of materials, from standard thermoplastics, engineering and high performance polymers to conductive polymers and thermoplastic elastomers. Now operating as a freelance consultant, he makes regular contributions to the European plastics trade press, and works with leading plastics industry consultants."}

Blends and Alloys of E...

$72.00

{"id":11242253956,"title":"Blends and Alloys of Engineering Thermoplastics","handle":"978-0-08041744-8","description":"\u003ch5\u003eDescription\u003c\/h5\u003e\nAuthor: H.T. van de Grampel \u003cbr\u003eISBN 978-0-08041744-8 \u003cbr\u003e\u003cbr\u003eGE Plastics BV\u003cbr\u003e\u003cbr\u003eReview Report\u003cbr\u003e132 pages, softbound\u003cbr\u003e\n\u003ch5\u003eSummary\u003c\/h5\u003e\nThis review report explains the theory of blending materials which may be essentially incompatible, and the properties and applications of commercially available blends of engineering thermoplastics are then described. \u003cbr\u003e\u003cbr\u003eExperimental results and data on commercial materials can be obtained from the accompanying references and abstracts (499).\u003cbr\u003e\u003cbr\u003e","published_at":"2017-06-22T21:15:27-04:00","created_at":"2017-06-22T21:15:27-04:00","vendor":"Chemtec Publishing","type":"Book","tags":["1991","alloys","applications","blends","book","morphology","p-structural","physical properties","polymer","thermoplastics"],"price":7200,"price_min":7200,"price_max":7200,"available":true,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":43378488004,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Blends and Alloys of Engineering Thermoplastics","public_title":null,"options":["Default Title"],"price":7200,"weight":1000,"compare_at_price":null,"inventory_quantity":1,"inventory_management":null,"inventory_policy":"continue","barcode":"978-0-08041744-8","requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/chemtec.org\/cdn\/shop\/products\/978-0-08041744-8.jpg?v=1499189446"],"featured_image":"\/\/chemtec.org\/cdn\/shop\/products\/978-0-08041744-8.jpg?v=1499189446","options":["Title"],"media":[{"alt":null,"id":353915338845,"position":1,"preview_image":{"aspect_ratio":0.767,"height":450,"width":345,"src":"\/\/chemtec.org\/cdn\/shop\/products\/978-0-08041744-8.jpg?v=1499189446"},"aspect_ratio":0.767,"height":450,"media_type":"image","src":"\/\/chemtec.org\/cdn\/shop\/products\/978-0-08041744-8.jpg?v=1499189446","width":345}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003ch5\u003eDescription\u003c\/h5\u003e\nAuthor: H.T. van de Grampel \u003cbr\u003eISBN 978-0-08041744-8 \u003cbr\u003e\u003cbr\u003eGE Plastics BV\u003cbr\u003e\u003cbr\u003eReview Report\u003cbr\u003e132 pages, softbound\u003cbr\u003e\n\u003ch5\u003eSummary\u003c\/h5\u003e\nThis review report explains the theory of blending materials which may be essentially incompatible, and the properties and applications of commercially available blends of engineering thermoplastics are then described. \u003cbr\u003e\u003cbr\u003eExperimental results and data on commercial materials can be obtained from the accompanying references and abstracts (499).\u003cbr\u003e\u003cbr\u003e"}